Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 57042..57601 Replicon plasmid unnamed7
Accession NZ_CP122866
Organism Escherichia coli strain ETEC1720

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag QDY31_RS25195 Protein ID WP_000421259.1
Coordinates 57326..57601 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag QDY31_RS25190 Protein ID WP_001178087.1
Coordinates 57042..57326 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY31_RS25170 (52689) 52689..53222 - 534 WP_001306770.1 transcription termination/antitermination NusG family protein -
QDY31_RS25175 (53664) 53664..53951 - 288 WP_000074849.1 conjugal transfer protein TraA -
QDY31_RS25180 (53869) 53869..54147 - 279 WP_219065241.1 ash family protein -
QDY31_RS25185 (55105) 55105..56136 + 1032 WP_000907862.1 plasmid replication initiator RepA -
QDY31_RS25190 (57042) 57042..57326 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
QDY31_RS25195 (57326) 57326..57601 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDY31_RS25200 (57707) 57707..57910 + 204 Protein_55 hypothetical protein -
QDY31_RS25205 (58412) 58412..59935 - 1524 Protein_56 Tn3 family transposase -
QDY31_RS25210 (59997) 59997..60749 + 753 WP_000602738.1 IS6 family transposase -
QDY31_RS25215 (60809) 60809..61096 - 288 Protein_58 AAC(3) family N-acetyltransferase -
QDY31_RS25220 (61171) 61171..62196 - 1026 WP_000742814.1 aminoglycoside O-phosphotransferase APH(4)-Ia -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(4)-Ia / aac(3)-IVa / blaTEM-52B / tet(A) / sul2 / aph(3'')-Ib / aph(6)-Id - 1..105313 105313


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T278104 WP_000421259.1 NZ_CP122866:57326-57601 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT278104 WP_001178087.1 NZ_CP122866:57042-57326 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References