Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4013866..4014442 Replicon chromosome
Accession NZ_CP122859
Organism Escherichia coli strain ETEC1720

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDY31_RS19700 Protein ID WP_001297643.1
Coordinates 4014155..4014442 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QDY31_RS19695 Protein ID WP_000063156.1
Coordinates 4013866..4014168 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY31_RS19680 (4010462) 4010462..4012612 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDY31_RS19685 (4012662) 4012662..4012865 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDY31_RS19690 (4012876) 4012876..4013832 + 957 WP_001297640.1 GTPase -
QDY31_RS19695 (4013866) 4013866..4014168 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QDY31_RS19700 (4014155) 4014155..4014442 - 288 WP_001297643.1 BrnT family toxin Toxin
QDY31_RS19705 (4014641) 4014641..4015338 - 698 Protein_3854 IS1 family transposase -
QDY31_RS19710 (4015395) 4015395..4015490 + 96 Protein_3855 dienelactone hydrolase family protein -
QDY31_RS19715 (4015636) 4015636..4016868 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
QDY31_RS19720 (4016909) 4016909..4018189 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T278094 WP_001297643.1 NZ_CP122859:c4014442-4014155 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT278094 WP_000063156.1 NZ_CP122859:c4014168-4013866 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References