Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3469832..3470450 Replicon chromosome
Accession NZ_CP122859
Organism Escherichia coli strain ETEC1720

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDY31_RS16980 Protein ID WP_001291435.1
Coordinates 3470232..3470450 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDY31_RS16975 Protein ID WP_000344800.1
Coordinates 3469832..3470206 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY31_RS16965 (3464921) 3464921..3466114 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDY31_RS16970 (3466137) 3466137..3469286 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDY31_RS16975 (3469832) 3469832..3470206 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDY31_RS16980 (3470232) 3470232..3470450 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDY31_RS16985 (3470622) 3470622..3471173 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDY31_RS16990 (3471289) 3471289..3471759 + 471 WP_000136192.1 YlaC family protein -
QDY31_RS16995 (3471923) 3471923..3473473 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDY31_RS17000 (3473515) 3473515..3473868 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDY31_RS17010 (3474247) 3474247..3474558 + 312 WP_000409911.1 MGMT family protein -
QDY31_RS17015 (3474589) 3474589..3475161 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278093 WP_001291435.1 NZ_CP122859:3470232-3470450 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278093 WP_000344800.1 NZ_CP122859:3469832-3470206 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References