Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2487391..2488029 Replicon chromosome
Accession NZ_CP122859
Organism Escherichia coli strain ETEC1720

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDY31_RS12170 Protein ID WP_000813794.1
Coordinates 2487853..2488029 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDY31_RS12165 Protein ID WP_001270286.1
Coordinates 2487391..2487807 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY31_RS12145 (2482543) 2482543..2483484 - 942 WP_087905458.1 ABC transporter permease -
QDY31_RS12150 (2483485) 2483485..2484498 - 1014 WP_097740840.1 ABC transporter ATP-binding protein -
QDY31_RS12155 (2484516) 2484516..2485661 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDY31_RS12160 (2485906) 2485906..2487312 - 1407 WP_000760585.1 PLP-dependent aminotransferase family protein -
QDY31_RS12165 (2487391) 2487391..2487807 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDY31_RS12170 (2487853) 2487853..2488029 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDY31_RS12175 (2488251) 2488251..2488481 + 231 WP_196010979.1 YncJ family protein -
QDY31_RS12180 (2488573) 2488573..2490534 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDY31_RS12185 (2490607) 2490607..2491143 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
QDY31_RS12190 (2491235) 2491235..2492410 + 1176 WP_001236251.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2492450..2493715 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T278092 WP_000813794.1 NZ_CP122859:c2488029-2487853 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT278092 WP_001270286.1 NZ_CP122859:c2487807-2487391 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References