278090

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2308173..2308699 Replicon chromosome
Accession NZ_CP122859
Organism Escherichia coli strain ETEC1720

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QDY31_RS11335 Protein ID WP_000323025.1
Coordinates 2308412..2308699 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QDY31_RS11330 Protein ID WP_000534858.1
Coordinates 2308173..2308412 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY31_RS11295 (2303287) 2303287..2303538 + 252 Protein_2209 DUF977 family protein -
QDY31_RS11300 (2303535) 2303535..2304024 + 490 Protein_2210 class I SAM-dependent methyltransferase -
QDY31_RS11305 (2304502) 2304502..2304923 + 422 Protein_2211 hypothetical protein -
QDY31_RS11310 (2305579) 2305579..2306649 + 1071 Protein_2212 ISNCY family transposase -
QDY31_RS11315 (2306722) 2306722..2306871 + 150 WP_011443592.1 protein YdfW -
QDY31_RS11320 (2307308) 2307308..2307640 - 333 WP_001301033.1 FlxA-like family protein -
QDY31_RS11325 (2307843) 2307843..2308148 - 306 WP_001326990.1 protein YdfV -
QDY31_RS11330 (2308173) 2308173..2308412 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QDY31_RS11335 (2308412) 2308412..2308699 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QDY31_RS11340 (2308771) 2308771..2308926 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QDY31_RS11345 (2309143) 2309143..2309394 + 252 WP_000980999.1 protein Rem -
QDY31_RS11350 (2309461) 2309461..2309739 + 279 WP_023147795.1 hypothetical protein -
QDY31_RS11355 (2309741) 2309741..2310790 + 1050 WP_196010922.1 DUF968 domain-containing protein -
QDY31_RS11360 (2310808) 2310808..2311185 + 378 WP_196010923.1 antiterminator Q family protein -
QDY31_RS11365 (2311341) 2311341..2311865 - 525 WP_000780584.1 lipocalin family protein -
QDY31_RS11370 (2312058) 2312058..2313017 + 960 WP_000592549.1 DUF523 and DUF1722 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2289668..2343656 53988


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T278090 WP_000323025.1 NZ_CP122859:2308412-2308699 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT278090 WP_000534858.1 NZ_CP122859:2308173-2308412 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References