Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 66868..67415 Replicon plasmid unnamed7
Accession NZ_CP122851
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QDX00_RS25330 Protein ID WP_001384452.1
Coordinates 67137..67415 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QDX00_RS25325 Protein ID WP_000079941.1
Coordinates 66868..67137 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX00_RS25295 (62042) 62042..62500 - 459 Protein_75 transposase -
QDX00_RS25300 (62578) 62578..62727 - 150 Protein_76 transposase -
QDX00_RS25305 (63235) 63235..63453 + 219 WP_001353651.1 heat-stable enterotoxin ST-I group a -
QDX00_RS25315 (65037) 65037..65429 - 393 Protein_79 IS21-like element IS21 family helper ATPase IstB -
QDX00_RS25320 (65429) 65429..66601 - 1173 WP_015056461.1 IS21-like element IS21 family transposase -
QDX00_RS25325 (66868) 66868..67137 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDX00_RS25330 (67137) 67137..67415 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QDX00_RS25335 (67724) 67724..68866 + 1143 WP_158649904.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
QDX00_RS25340 (68839) 68839..68943 + 105 Protein_84 hypothetical protein -
QDX00_RS25345 (68955) 68955..69260 + 306 WP_000482654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa / hlyD / hlyB / hlyB / hlyA / hlyC 1..107571 107571
- inside IScluster/Tn - estIa 56204..81523 25319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T278077 WP_001384452.1 NZ_CP122851:67137-67415 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT278077 WP_000079941.1 NZ_CP122851:66868-67137 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References