Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 38787..39388 Replicon plasmid unnamed4
Accession NZ_CP122848
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name doc Uniprot ID F4TND7
Locus tag QDX00_RS24060 Protein ID WP_001216030.1
Coordinates 38787..39167 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QDX00_RS24065 Protein ID WP_001190712.1
Coordinates 39167..39388 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX00_RS24035 (QDX00_24035) 34228..35712 - 1485 WP_000124150.1 terminase -
QDX00_RS24040 (QDX00_24040) 35712..36905 - 1194 WP_047649469.1 hypothetical protein -
QDX00_RS24045 (QDX00_24045) 36991..37443 - 453 WP_016231381.1 hypothetical protein -
QDX00_RS24050 (QDX00_24050) 37532..38575 - 1044 WP_047649471.1 DUF968 domain-containing protein -
QDX00_RS24055 (QDX00_24055) 38603..38782 - 180 WP_000113018.1 hypothetical protein -
QDX00_RS24060 (QDX00_24060) 38787..39167 - 381 WP_001216030.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QDX00_RS24065 (QDX00_24065) 39167..39388 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QDX00_RS24070 (QDX00_24070) 39571..41127 + 1557 WP_282836031.1 type I restriction-modification system subunit M -
QDX00_RS24075 (QDX00_24075) 41124..42257 + 1134 WP_282836025.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1A / floR - 1..98832 98832


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13601.29 Da        Isoelectric Point: 5.1408

>T278074 WP_001216030.1 NZ_CP122848:c39167-38787 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEDITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT278074 WP_001190712.1 NZ_CP122848:c39388-39167 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1W8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References