Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 57043..57602 Replicon plasmid unnamed3
Accession NZ_CP122847
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name relE Uniprot ID U9YB49
Locus tag QDX00_RS23575 Protein ID WP_000421259.1
Coordinates 57327..57602 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag QDX00_RS23570 Protein ID WP_001178087.1
Coordinates 57043..57327 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX00_RS23550 (52690) 52690..53223 - 534 WP_001306770.1 transcription termination/antitermination NusG family protein -
QDX00_RS23555 (53665) 53665..53952 - 288 WP_000074849.1 conjugal transfer protein TraA -
QDX00_RS23560 (53870) 53870..54148 - 279 WP_219065241.1 ash family protein -
QDX00_RS23565 (55106) 55106..56137 + 1032 WP_000907862.1 plasmid replication initiator RepA -
QDX00_RS23570 (57043) 57043..57327 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
QDX00_RS23575 (57327) 57327..57602 + 276 WP_000421259.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX00_RS23580 (57708) 57708..57911 + 204 Protein_56 hypothetical protein -
QDX00_RS23585 (58413) 58413..59936 - 1524 Protein_57 Tn3 family transposase -
QDX00_RS23590 (59998) 59998..60750 + 753 WP_000602738.1 IS6 family transposase -
QDX00_RS23595 (60810) 60810..61097 - 288 Protein_59 AAC(3) family N-acetyltransferase -
QDX00_RS23600 (61172) 61172..62197 - 1026 WP_000742814.1 aminoglycoside O-phosphotransferase APH(4)-Ia -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(4)-Ia / aac(3)-IVa / blaTEM-52B / tet(A) / sul2 / aph(3'')-Ib / aph(6)-Id - 1..105315 105315


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.45 Da        Isoelectric Point: 9.9324

>T278073 WP_000421259.1 NZ_CP122847:57327-57602 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT278073 WP_001178087.1 NZ_CP122847:57043-57327 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YB49

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References