Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4010844..4011420 Replicon chromosome
Accession NZ_CP122844
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDX00_RS19655 Protein ID WP_001297643.1
Coordinates 4011133..4011420 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QDX00_RS19650 Protein ID WP_000063156.1
Coordinates 4010844..4011146 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX00_RS19635 (4007440) 4007440..4009590 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDX00_RS19640 (4009640) 4009640..4009843 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDX00_RS19645 (4009854) 4009854..4010810 + 957 WP_001297640.1 GTPase -
QDX00_RS19650 (4010844) 4010844..4011146 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QDX00_RS19655 (4011133) 4011133..4011420 - 288 WP_001297643.1 BrnT family toxin Toxin
QDX00_RS19660 (4011619) 4011619..4012316 - 698 Protein_3845 IS1 family transposase -
QDX00_RS19665 (4012373) 4012373..4012468 + 96 Protein_3846 dienelactone hydrolase family protein -
QDX00_RS19670 (4012614) 4012614..4013846 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
QDX00_RS19675 (4013887) 4013887..4015167 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T278066 WP_001297643.1 NZ_CP122844:c4011420-4011133 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT278066 WP_000063156.1 NZ_CP122844:c4011146-4010844 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References