Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3466829..3467447 Replicon chromosome
Accession NZ_CP122844
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDX00_RS16935 Protein ID WP_001291435.1
Coordinates 3467229..3467447 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDX00_RS16930 Protein ID WP_000344800.1
Coordinates 3466829..3467203 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX00_RS16920 (3461918) 3461918..3463111 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDX00_RS16925 (3463134) 3463134..3466283 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDX00_RS16930 (3466829) 3466829..3467203 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDX00_RS16935 (3467229) 3467229..3467447 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDX00_RS16940 (3467619) 3467619..3468170 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDX00_RS16945 (3468286) 3468286..3468756 + 471 WP_000136192.1 YlaC family protein -
QDX00_RS16950 (3468920) 3468920..3470470 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDX00_RS16955 (3470512) 3470512..3470865 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDX00_RS16965 (3471244) 3471244..3471555 + 312 WP_000409911.1 MGMT family protein -
QDX00_RS16970 (3471586) 3471586..3472158 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278064 WP_001291435.1 NZ_CP122844:3467229-3467447 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278064 WP_000344800.1 NZ_CP122844:3466829-3467203 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References