Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 851361..852015 Replicon chromosome
Accession NZ_CP122844
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QDX00_RS04225 Protein ID WP_000244777.1
Coordinates 851608..852015 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDX00_RS04220 Protein ID WP_000354046.1
Coordinates 851361..851627 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX00_RS04195 (846530) 846530..847273 + 744 WP_094313880.1 SDR family oxidoreductase -
QDX00_RS04200 (847330) 847330..848763 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
QDX00_RS04205 (848808) 848808..849119 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QDX00_RS04210 (849283) 849283..849942 + 660 WP_000250274.1 hemolysin III family protein -
QDX00_RS04215 (850138) 850138..851118 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QDX00_RS04220 (851361) 851361..851627 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDX00_RS04225 (851608) 851608..852015 + 408 WP_000244777.1 protein YgfX Toxin
QDX00_RS04230 (852055) 852055..852576 - 522 WP_001055874.1 flavodoxin FldB -
QDX00_RS04235 (852688) 852688..853584 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDX00_RS04240 (853609) 853609..854319 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDX00_RS04245 (854325) 854325..856058 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T278054 WP_000244777.1 NZ_CP122844:851608-852015 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278054 WP_000354046.1 NZ_CP122844:851361-851627 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References