Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 693786..694621 Replicon chromosome
Accession NZ_CP122844
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J5ZPW7
Locus tag QDX00_RS03385 Protein ID WP_000854722.1
Coordinates 694244..694621 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K4A940
Locus tag QDX00_RS03380 Protein ID WP_001285576.1
Coordinates 693786..694154 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX00_RS03360 (691538) 691538..692356 + 819 WP_169029782.1 DUF932 domain-containing protein -
QDX00_RS03365 (692448) 692448..692930 + 483 WP_169029783.1 antirestriction protein -
QDX00_RS03370 (692946) 692946..693422 + 477 WP_053289735.1 RadC family protein -
QDX00_RS03375 (693485) 693485..693706 + 222 WP_089570377.1 DUF987 domain-containing protein -
QDX00_RS03380 (693786) 693786..694154 + 369 WP_001285576.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDX00_RS03385 (694244) 694244..694621 + 378 WP_000854722.1 TA system toxin CbtA family protein Toxin
QDX00_RS03390 (694618) 694618..695106 + 489 WP_000761669.1 DUF5983 family protein -
QDX00_RS03395 (695126) 695126..695323 + 198 WP_000445281.1 DUF957 domain-containing protein -
QDX00_RS03400 (695408) 695408..696253 + 846 WP_169029784.1 DUF4942 domain-containing protein -
QDX00_RS03410 (696553) 696553..697059 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
QDX00_RS03415 (697138) 697138..698979 - 1842 WP_282835911.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14103.15 Da        Isoelectric Point: 8.2904

>T278052 WP_000854722.1 NZ_CP122844:694244-694621 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13599.36 Da        Isoelectric Point: 6.3159

>AT278052 WP_001285576.1 NZ_CP122844:693786-694154 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5ZPW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K4A940

References