Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 45729..46276 Replicon plasmid unnamed6
Accession NZ_CP122843
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDW97_RS26995 Protein ID WP_013009346.1
Coordinates 45729..46007 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag QDW97_RS27000 Protein ID WP_000079932.1
Coordinates 46007..46276 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS26965 (41326) 41326..41691 + 366 WP_000124098.1 hypothetical protein -
QDW97_RS26970 (41691) 41691..42878 + 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDW97_RS26975 (43070) 43070..43630 + 561 Protein_51 IS91-like element IS91 family transposase -
QDW97_RS26980 (43811) 43811..44023 + 213 Protein_52 ProQ/FINO family protein -
QDW97_RS26985 (44305) 44305..44892 - 588 WP_024189984.1 serine acetyltransferase -
QDW97_RS26990 (45237) 45237..45533 + 297 WP_001419651.1 hypothetical protein -
QDW97_RS26995 (45729) 45729..46007 - 279 WP_013009346.1 type II toxin-antitoxin system toxin YacB Toxin
QDW97_RS27000 (46007) 46007..46276 - 270 WP_000079932.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDW97_RS27005 (47185) 47185..48216 - 1032 WP_000907873.1 plasmid replication initiator RepA -
QDW97_RS27010 (49174) 49174..49332 + 159 Protein_58 ash family protein -
QDW97_RS27015 (49370) 49370..49657 + 288 WP_000074855.1 conjugal transfer protein TraA -
QDW97_RS27020 (50099) 50099..50632 + 534 WP_001372168.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..96346 96346


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10748.35 Da        Isoelectric Point: 8.4615

>T278045 WP_013009346.1 NZ_CP122843:c46007-45729 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
VLRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10268.58 Da        Isoelectric Point: 7.2055

>AT278045 WP_000079932.1 NZ_CP122843:c46276-46007 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References