Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4451075..4451572 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDW97_RS21650 Protein ID WP_001173343.1
Coordinates 4451075..4451248 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW97_RS21655 Protein ID WP_000398619.1
Coordinates 4451276..4451572 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS21640 (4447744) 4447744..4449202 + 1459 Protein_4237 dipeptide/tripeptide permease DtpC -
QDW97_RS21645 (4449439) 4449439..4450956 + 1518 WP_001295087.1 lysine--tRNA ligase -
QDW97_RS21650 (4451075) 4451075..4451248 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW97_RS21655 (4451276) 4451276..4451572 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW97_RS21660 (4451799) 4451799..4452071 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDW97_RS21665 (4452083) 4452083..4452313 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
QDW97_RS21670 (4452494) 4452494..4454125 + 1632 WP_001216487.1 sensor histidine kinase -
QDW97_RS21675 (4454122) 4454122..4454841 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T278034 WP_001173343.1 NZ_CP122837:c4451248-4451075 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT278034 WP_000398619.1 NZ_CP122837:c4451572-4451276 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References