278032

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3562239..3563076 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag QDW97_RS17205 Protein ID WP_096262872.1
Coordinates 3562534..3563076 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QDW97_RS17200 Protein ID WP_001297137.1
Coordinates 3562239..3562550 (+) Length 104 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS17175 (3557259) 3557259..3558206 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
QDW97_RS17180 (3558228) 3558228..3560219 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QDW97_RS17185 (3560209) 3560209..3560823 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QDW97_RS17190 (3560823) 3560823..3561152 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QDW97_RS17195 (3561164) 3561164..3562054 + 891 WP_000971336.1 heme o synthase -
QDW97_RS17200 (3562239) 3562239..3562550 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QDW97_RS17205 (3562534) 3562534..3563076 + 543 WP_096262872.1 GNAT family N-acetyltransferase Toxin
QDW97_RS17210 (3563132) 3563132..3564067 - 936 WP_001297127.1 tetratricopeptide repeat protein -
QDW97_RS17215 (3564475) 3564475..3565839 + 1365 WP_001000978.1 MFS transporter -
QDW97_RS17220 (3565967) 3565967..3566458 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QDW97_RS17225 (3566626) 3566626..3567537 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(68-156)

Antitoxin

(14-97)


Sequences


Toxin        


Download         Length: 181 a.a.        Molecular weight: 19804.03 Da        Isoelectric Point: 8.6178

>T278032 WP_096262872.1 NZ_CP122837:3562534-3563076 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSNITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp


Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT278032 WP_001297137.1 NZ_CP122837:3562239-3562550 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References