Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3528159..3528777 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW97_RS17035 Protein ID WP_001291435.1
Coordinates 3528559..3528777 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW97_RS17030 Protein ID WP_000344800.1
Coordinates 3528159..3528533 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS17020 (3523247) 3523247..3524440 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW97_RS17025 (3524463) 3524463..3527613 + 3151 Protein_3331 efflux RND transporter permease AcrB -
QDW97_RS17030 (3528159) 3528159..3528533 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW97_RS17035 (3528559) 3528559..3528777 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW97_RS17040 (3528949) 3528949..3529500 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW97_RS17045 (3529616) 3529616..3530086 + 471 WP_000136192.1 YlaC family protein -
QDW97_RS17050 (3530250) 3530250..3531800 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW97_RS17055 (3531842) 3531842..3532195 - 354 WP_000878141.1 DUF1428 family protein -
QDW97_RS17065 (3532574) 3532574..3532885 + 312 WP_000409911.1 MGMT family protein -
QDW97_RS17070 (3532916) 3532916..3533488 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278031 WP_001291435.1 NZ_CP122837:3528559-3528777 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278031 WP_000344800.1 NZ_CP122837:3528159-3528533 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References