Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2560631..2561269 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDW97_RS12335 Protein ID WP_000813794.1
Coordinates 2561093..2561269 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW97_RS12330 Protein ID WP_001270286.1
Coordinates 2560631..2561047 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS12310 (2555784) 2555784..2556725 - 942 WP_001251315.1 ABC transporter permease -
QDW97_RS12315 (2556726) 2556726..2557739 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
QDW97_RS12320 (2557757) 2557757..2558902 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QDW97_RS12325 (2559147) 2559147..2560552 - 1406 Protein_2415 PLP-dependent aminotransferase family protein -
QDW97_RS12330 (2560631) 2560631..2561047 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW97_RS12335 (2561093) 2561093..2561269 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW97_RS12340 (2561491) 2561491..2561721 + 231 WP_000494239.1 YncJ family protein -
QDW97_RS12345 (2561813) 2561813..2563774 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW97_RS12350 (2563847) 2563847..2564383 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDW97_RS12355 (2564475) 2564475..2565650 + 1176 WP_001236258.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T278030 WP_000813794.1 NZ_CP122837:c2561269-2561093 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT278030 WP_001270286.1 NZ_CP122837:c2561047-2560631 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References