Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 28682..29207 Replicon plasmid pO157
Accession NC_017907
Organism Escherichia coli Xuzhou21

Toxin (Protein)


Gene name ccdB Uniprot ID V0SSI5
Locus tag CDCO157_RS27685 Protein ID WP_001159868.1
Coordinates 28902..29207 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag CDCO157_RS27680 Protein ID WP_000813634.1
Coordinates 28682..28900 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDCO157_RS31735 23965..24195 + 231 WP_010891288.1 hypothetical protein -
CDCO157_RS27645 24316..25056 + 741 WP_001066920.1 tyrosine-type recombinase/integrase -
CDCO157_RS27650 25341..26318 - 978 WP_000361615.1 RepB family plasmid replication initiator protein -
CDCO157_RS27660 26726..26926 - 201 WP_000708307.1 hypothetical protein -
CDCO157_RS27665 26923..27543 - 621 WP_001248529.1 hypothetical protein -
CDCO157_RS27670 27540..28223 - 684 WP_010891291.1 DNA-binding protein -
CDCO157_RS27680 28682..28900 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
CDCO157_RS27685 28902..29207 + 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB Toxin
CDCO157_RS27690 29208..30014 + 807 WP_000016989.1 site-specific integrase -
CDCO157_RS30700 31912..32250 + 339 WP_071525396.1 RepB family plasmid replication initiator protein -
CDCO157_RS27705 32838..34004 + 1167 WP_000772446.1 plasmid-partitioning protein SopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - stcE / exeE / exeG / hlyC / hlyA / hlyB / hlyD / toxB / espP 1..92728 92728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11706.51 Da        Isoelectric Point: 6.4674

>T27803 WP_001159868.1 NC_017907:28902-29207 [Escherichia coli Xuzhou21]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T27803 NC_017907:28902-29207 [Escherichia coli Xuzhou21]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT27803 WP_000813634.1 NC_017907:28682-28900 [Escherichia coli Xuzhou21]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT27803 NC_017907:28682-28900 [Escherichia coli Xuzhou21]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4VUB
PDB 2VUB
PDB 7EPI
PDB 7EPG
PDB 3VUB
PDB 1X75
PDB 1VUB
PDB 7EPJ
PDB 3HPW
PDB 3G7Z

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References