Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1437064..1437689 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag QDW97_RS07005 Protein ID WP_000911329.1
Coordinates 1437291..1437689 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QDW97_RS07000 Protein ID WP_000450524.1
Coordinates 1437064..1437291 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS06975 (1432866) 1432866..1433336 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QDW97_RS06980 (1433336) 1433336..1433908 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QDW97_RS06985 (1434054) 1434054..1434932 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QDW97_RS06990 (1434949) 1434949..1435983 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QDW97_RS06995 (1436196) 1436196..1436909 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QDW97_RS07000 (1437064) 1437064..1437291 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDW97_RS07005 (1437291) 1437291..1437689 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
QDW97_RS07010 (1437836) 1437836..1438699 + 864 WP_001267498.1 neutral zinc metallopeptidase -
QDW97_RS07015 (1438714) 1438714..1440729 + 2016 WP_000829393.1 tRNA cytosine(34) acetyltransferase TmcA -
QDW97_RS07020 (1440803) 1440803..1441501 + 699 WP_000679812.1 esterase -
QDW97_RS07025 (1441611) 1441611..1441811 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T278024 WP_000911329.1 NZ_CP122837:1437291-1437689 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT278024 WP_000450524.1 NZ_CP122837:1437064-1437291 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References