Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1007906..1008560 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag QDW97_RS04980 Protein ID WP_000244781.1
Coordinates 1008153..1008560 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW97_RS04975 Protein ID WP_000354046.1
Coordinates 1007906..1008172 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS04955 (1003994) 1003994..1005427 - 1434 WP_139501107.1 6-phospho-beta-glucosidase BglA -
QDW97_RS04960 (1005472) 1005472..1005783 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QDW97_RS04965 (1005947) 1005947..1006606 + 660 WP_000250274.1 hemolysin III family protein -
QDW97_RS04970 (1006683) 1006683..1007663 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
QDW97_RS04975 (1007906) 1007906..1008172 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW97_RS04980 (1008153) 1008153..1008560 + 408 WP_000244781.1 protein YgfX Toxin
QDW97_RS04985 (1008600) 1008600..1009121 - 522 WP_001055874.1 flavodoxin FldB -
QDW97_RS04990 (1009233) 1009233..1010129 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDW97_RS04995 (1010154) 1010154..1010864 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW97_RS05000 (1010870) 1010870..1012603 + 1734 WP_096262898.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T278023 WP_000244781.1 NZ_CP122837:1008153-1008560 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT278023 WP_000354046.1 NZ_CP122837:1007906-1008172 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References