Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 788042..788877 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J5ZPW7
Locus tag QDW97_RS03865 Protein ID WP_000854722.1
Coordinates 788500..788877 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7U9D1
Locus tag QDW97_RS03860 Protein ID WP_024168534.1
Coordinates 788042..788410 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS03820 (783975) 783975..784181 + 207 WP_000668905.1 hypothetical protein -
QDW97_RS03825 (784257) 784257..784481 + 225 WP_000459736.1 hypothetical protein -
QDW97_RS03830 (784668) 784668..784907 + 240 WP_001255978.1 hypothetical protein -
QDW97_RS03835 (784926) 784926..785408 + 483 WP_000649890.1 hypothetical protein -
QDW97_RS03840 (785767) 785767..786585 + 819 WP_001234707.1 DUF932 domain-containing protein -
QDW97_RS03845 (786677) 786677..787162 + 486 WP_000214415.1 antirestriction protein -
QDW97_RS03850 (787178) 787178..787654 + 477 WP_001186725.1 RadC family protein -
QDW97_RS03855 (787741) 787741..787962 + 222 WP_000692350.1 DUF987 domain-containing protein -
QDW97_RS03860 (788042) 788042..788410 + 369 WP_024168534.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDW97_RS03865 (788500) 788500..788877 + 378 WP_000854722.1 TA system toxin CbtA family protein Toxin
QDW97_RS03870 (788874) 788874..789362 + 489 WP_000761669.1 DUF5983 family protein -
QDW97_RS03875 (789382) 789382..789579 + 198 WP_000445281.1 DUF957 domain-containing protein -
QDW97_RS03880 (789664) 789664..790509 + 846 WP_001280434.1 DUF4942 domain-containing protein -
QDW97_RS03890 (790809) 790809..791315 + 507 WP_282843695.1 G/U mismatch-specific DNA glycosylase -
QDW97_RS03895 (791394) 791394..793235 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14103.15 Da        Isoelectric Point: 8.2904

>T278022 WP_000854722.1 NZ_CP122837:788500-788877 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13622.44 Da        Isoelectric Point: 6.3159

>AT278022 WP_024168534.1 NZ_CP122837:788042-788410 [Escherichia coli]
VSDILPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5ZPW7

Antitoxin

Source ID Structure

References