Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 318585..319216 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag QDW97_RS01500 Protein ID WP_001259385.1
Coordinates 318585..318860 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag QDW97_RS01505 Protein ID WP_000593554.1
Coordinates 318857..319216 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS01485 (313589) 313589..314656 + 1068 WP_000361467.1 HlyD family secretion protein -
QDW97_RS01490 (314653) 314653..317388 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
QDW97_RS01495 (317388) 317388..318512 + 1125 WP_001314210.1 ABC transporter permease -
QDW97_RS01500 (318585) 318585..318860 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
QDW97_RS01505 (318857) 318857..319216 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDW97_RS01510 (319266) 319266..320126 - 861 WP_001131782.1 class II aldolase -
QDW97_RS01515 (320158) 320158..320427 - 270 WP_000933060.1 HPr family phosphocarrier protein -
QDW97_RS01520 (320417) 320417..321925 - 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
QDW97_RS01525 (321918) 321918..323276 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
QDW97_RS01530 (323353) 323353..323634 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
QDW97_RS01535 (323631) 323631..324104 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 310967..325475 14508
- inside Genomic island - - 310967..319216 8249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T278020 WP_001259385.1 NZ_CP122837:318585-318860 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT278020 WP_000593554.1 NZ_CP122837:318857-319216 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References