Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49059..49891 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VCF5
Locus tag QDW97_RS00255 Protein ID WP_000854681.1
Coordinates 49059..49436 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QDW97_RS00260 Protein ID WP_088474659.1
Coordinates 49526..49891 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS00225 (44698) 44698..45621 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
QDW97_RS00230 (45732) 45732..46917 - 1186 Protein_45 sugar efflux transporter -
QDW97_RS00235 (47346) 47346..47474 - 129 Protein_46 RhuM family protein -
QDW97_RS00240 (47712) 47712..48555 - 844 Protein_47 DUF4942 domain-containing protein -
QDW97_RS00245 (48640) 48640..48837 - 198 WP_023563519.1 DUF957 domain-containing protein -
QDW97_RS00250 (48913) 48913..49062 - 150 Protein_49 DUF5983 family protein -
QDW97_RS00255 (49059) 49059..49436 - 378 WP_000854681.1 TA system toxin CbtA family protein Toxin
QDW97_RS00260 (49526) 49526..49891 - 366 WP_088474659.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDW97_RS00265 (49969) 49969..50190 - 222 WP_000692300.1 DUF987 domain-containing protein -
QDW97_RS00270 (50253) 50253..50729 - 477 WP_001424026.1 RadC family protein -
QDW97_RS00275 (50745) 50745..51230 - 486 WP_000206658.1 antirestriction protein -
QDW97_RS00280 (51322) 51322..52140 - 819 WP_001234615.1 DUF932 domain-containing protein -
QDW97_RS00285 (52239) 52239..52472 - 234 WP_001278287.1 DUF905 family protein -
QDW97_RS00290 (52478) 52478..53155 - 678 WP_001097305.1 hypothetical protein -
QDW97_RS00295 (53303) 53303..53983 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13963.89 Da        Isoelectric Point: 7.4348

>T278019 WP_000854681.1 NZ_CP122837:c49436-49059 [Escherichia coli]
MKTLPDTHIREASHCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTSHNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13554.36 Da        Isoelectric Point: 6.2034

>AT278019 WP_088474659.1 NZ_CP122837:c49891-49526 [Escherichia coli]
VSDTLPGTTYPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKT

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VCF5

Antitoxin

Source ID Structure

References