278014

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 36442..37085 Replicon plasmid unnamed3
Accession NZ_CP122835
Organism Escherichia coli strain ETEC1730

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag QDY27_RS26835 Protein ID WP_001044768.1
Coordinates 36669..37085 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag QDY27_RS26830 Protein ID WP_001261287.1
Coordinates 36442..36672 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY27_RS26810 (31602) 31602..32690 + 1089 WP_000952217.1 transcriptional repressor PifC -
QDY27_RS26815 (32692) 32692..34917 + 2226 WP_000698737.1 P-loop NTPase fold protein -
QDY27_RS26820 (34967) 34967..35866 - 900 WP_000963206.1 nucleotide-binding protein -
QDY27_RS26825 (35856) 35856..36146 - 291 WP_000111771.1 hypothetical protein -
QDY27_RS26830 (36442) 36442..36672 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QDY27_RS26835 (36669) 36669..37085 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
QDY27_RS26840 (37247) 37247..39385 - 2139 WP_000350639.1 AAA family ATPase -
QDY27_RS26845 (39893) 39893..40597 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
QDY27_RS26850 (40660) 40660..40755 + 96 Protein_46 helix-turn-helix domain-containing protein -
QDY27_RS26855 (40938) 40938..41798 + 861 WP_000027057.1 broad-spectrum class A beta-lactamase TEM-1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / aph(3')-Ia - 1..104099 104099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T278014 WP_001044768.1 NZ_CP122835:36669-37085 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT278014 WP_001261287.1 NZ_CP122835:36442-36672 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References