Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 4838..5463 | Replicon | plasmid unnamed2 |
Accession | NZ_CP122834 | ||
Organism | Escherichia coli strain ETEC1730 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | QDY27_RS25770 | Protein ID | WP_000911317.1 |
Coordinates | 5065..5463 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | L4J1D2 |
Locus tag | QDY27_RS25765 | Protein ID | WP_000450532.1 |
Coordinates | 4838..5065 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QDY27_RS25730 (1) | 1..963 | + | 963 | WP_032084392.1 | ParB family protein | - |
QDY27_RS25735 (1103) | 1103..1276 | - | 174 | Protein_2 | DUF4113 domain-containing protein | - |
QDY27_RS25740 (1350) | 1350..1775 | + | 426 | WP_024193300.1 | antirestriction protein | - |
QDY27_RS25745 (1812) | 1812..1943 | - | 132 | Protein_4 | transposase | - |
QDY27_RS25750 (2132) | 2132..3319 | - | 1188 | WP_000937614.1 | IS91-like element IS91 family transposase | - |
QDY27_RS25755 (3319) | 3319..3684 | - | 366 | WP_000124098.1 | hypothetical protein | - |
QDY27_RS25760 (3773) | 3773..4756 | - | 984 | Protein_7 | MobF family relaxase | - |
QDY27_RS25765 (4838) | 4838..5065 | + | 228 | WP_000450532.1 | toxin-antitoxin system antitoxin VapB | Antitoxin |
QDY27_RS25770 (5065) | 5065..5463 | + | 399 | WP_000911317.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
QDY27_RS25775 (5615) | 5615..6805 | - | 1191 | Protein_10 | type IV conjugative transfer system coupling protein TraD | - |
QDY27_RS25780 (7056) | 7056..7787 | - | 732 | WP_023565183.1 | conjugal transfer complement resistance protein TraT | - |
QDY27_RS25785 (7819) | 7819..8316 | - | 498 | WP_282843564.1 | entry exclusion protein | - |
QDY27_RS25790 (8332) | 8332..9366 | - | 1035 | Protein_13 | conjugal transfer protein TraG | - |
QDY27_RS25795 (9364) | 9364..9795 | + | 432 | Protein_14 | transposase | - |
QDY27_RS25800 (10093) | 10093..10263 | + | 171 | WP_227432179.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | hlyD / hlyC / hlyA / hlyB / hlyD | 1..165083 | 165083 | |
- | flank | IS/Tn | - | - | 2132..3364 | 1232 | |
- | flank | IS/Tn | - | - | 9352..9795 | 443 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14857.14 Da Isoelectric Point: 8.5264
>T278007 WP_000911317.1 NZ_CP122834:5065-5463 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS
Download Length: 399 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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