Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 19456..20057 Replicon plasmid unnamed1
Accession NZ_CP122833
Organism Escherichia coli strain ETEC1730

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag QDY27_RS25335 Protein ID WP_001216045.1
Coordinates 19456..19836 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QDY27_RS25340 Protein ID WP_001190712.1
Coordinates 19836..20057 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY27_RS25310 (QDY27_25310) 14897..16381 - 1485 WP_000124150.1 terminase -
QDY27_RS25315 (QDY27_25315) 16381..17574 - 1194 WP_000219616.1 hypothetical protein -
QDY27_RS25320 (QDY27_25320) 17660..18112 - 453 WP_032192895.1 Late promoter-activating protein -
QDY27_RS25325 (QDY27_25325) 18201..19244 - 1044 WP_072660937.1 DUF968 domain-containing protein -
QDY27_RS25330 (QDY27_25330) 19272..19451 - 180 WP_000113018.1 hypothetical protein -
QDY27_RS25335 (QDY27_25335) 19456..19836 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QDY27_RS25340 (QDY27_25340) 19836..20057 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QDY27_RS25345 (QDY27_25345) 20240..21796 + 1557 WP_086186057.1 type I restriction-modification system subunit M -
QDY27_RS25350 (QDY27_25350) 21793..22974 + 1182 WP_120150456.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91199 91199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T278006 WP_001216045.1 NZ_CP122833:c19836-19456 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT278006 WP_001190712.1 NZ_CP122833:c20057-19836 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References