Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3765630..3766248 Replicon chromosome
Accession NZ_CP122832
Organism Escherichia coli strain ETEC1730

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDY27_RS18960 Protein ID WP_001291435.1
Coordinates 3766030..3766248 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDY27_RS18955 Protein ID WP_000344800.1
Coordinates 3765630..3766004 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY27_RS18945 (3760719) 3760719..3761912 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDY27_RS18950 (3761935) 3761935..3765084 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDY27_RS18955 (3765630) 3765630..3766004 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDY27_RS18960 (3766030) 3766030..3766248 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDY27_RS18965 (3766420) 3766420..3766971 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDY27_RS18970 (3767087) 3767087..3767557 + 471 WP_000136192.1 YlaC family protein -
QDY27_RS18975 (3767721) 3767721..3769271 + 1551 WP_094336394.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDY27_RS18980 (3769313) 3769313..3769666 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDY27_RS18990 (3770045) 3770045..3770356 + 312 WP_000409911.1 MGMT family protein -
QDY27_RS18995 (3770387) 3770387..3770959 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T278003 WP_001291435.1 NZ_CP122832:3766030-3766248 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT278003 WP_000344800.1 NZ_CP122832:3765630-3766004 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References