Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2577646..2578284 Replicon chromosome
Accession NZ_CP122832
Organism Escherichia coli strain ETEC1730

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDY27_RS12700 Protein ID WP_000813794.1
Coordinates 2578108..2578284 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDY27_RS12695 Protein ID WP_282843529.1
Coordinates 2577646..2578062 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY27_RS12675 (2572798) 2572798..2573739 - 942 WP_001251304.1 ABC transporter permease -
QDY27_RS12680 (2573740) 2573740..2574753 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QDY27_RS12685 (2574771) 2574771..2575916 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDY27_RS12690 (2576161) 2576161..2577567 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QDY27_RS12695 (2577646) 2577646..2578062 - 417 WP_282843529.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDY27_RS12700 (2578108) 2578108..2578284 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDY27_RS12705 (2578506) 2578506..2578736 + 231 WP_000494244.1 YncJ family protein -
QDY27_RS12710 (2578828) 2578828..2580789 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDY27_RS12715 (2580862) 2580862..2581398 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDY27_RS12720 (2581490) 2581490..2582665 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T278002 WP_000813794.1 NZ_CP122832:c2578284-2578108 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15197.56 Da        Isoelectric Point: 4.7358

>AT278002 WP_282843529.1 NZ_CP122832:c2578062-2577646 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEIAHLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References