Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 913793..914447 Replicon chromosome
Accession NZ_CP122832
Organism Escherichia coli strain ETEC1730

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QDY27_RS04430 Protein ID WP_000244777.1
Coordinates 914040..914447 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDY27_RS04425 Protein ID WP_000354046.1
Coordinates 913793..914059 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY27_RS04405 (909762) 909762..911195 - 1434 WP_001514525.1 6-phospho-beta-glucosidase BglA -
QDY27_RS04410 (911240) 911240..911551 + 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
QDY27_RS04415 (911715) 911715..912374 + 660 WP_000250274.1 hemolysin III family protein -
QDY27_RS04420 (912570) 912570..913550 - 981 WP_001514522.1 tRNA-modifying protein YgfZ -
QDY27_RS04425 (913793) 913793..914059 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDY27_RS04430 (914040) 914040..914447 + 408 WP_000244777.1 protein YgfX Toxin
QDY27_RS04435 (914487) 914487..915008 - 522 WP_001055874.1 flavodoxin FldB -
QDY27_RS04440 (915120) 915120..916016 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDY27_RS04445 (916041) 916041..916751 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDY27_RS04450 (916757) 916757..918490 + 1734 WP_032187585.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T277996 WP_000244777.1 NZ_CP122832:914040-914447 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277996 WP_000354046.1 NZ_CP122832:913793-914059 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References