Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 70999..71546 Replicon plasmid unnamed4
Accession NZ_CP122827
Organism Escherichia coli strain ETEC1732

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDX01_RS26995 Protein ID WP_244442846.1
Coordinates 71268..71546 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QDX01_RS26990 Protein ID WP_000079941.1
Coordinates 70999..71268 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX01_RS26960 (66079) 66079..66783 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
QDX01_RS26965 (66835) 66835..67428 + 594 Protein_86 IS110-like element IS5075 family transposase -
QDX01_RS26970 (67700) 67700..67786 - 87 Protein_87 Arm DNA-binding domain-containing protein -
QDX01_RS26975 (68116) 68116..68931 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
QDX01_RS26980 (69018) 69018..69260 + 243 Protein_89 phosphoglucosamine mutase -
QDX01_RS26985 (69496) 69496..70641 - 1146 Protein_90 IS91-like element ISVsa3 family transposase -
QDX01_RS26990 (70999) 70999..71268 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDX01_RS26995 (71268) 71268..71546 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
QDX01_RS27000 (71586) 71586..72434 + 849 WP_021265674.1 3'-5' exonuclease -
QDX01_RS27005 (72575) 72575..73024 + 450 WP_001236003.1 hypothetical protein -
QDX01_RS27010 (73501) 73501..73767 - 267 WP_000955263.1 hypothetical protein -
QDX01_RS27015 (73767) 73767..74261 - 495 WP_001459505.1 hypothetical protein -
QDX01_RS27020 (74317) 74317..74919 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aadA5 / sul2 - 1..80827 80827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T277983 WP_244442846.1 NZ_CP122827:71268-71546 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT277983 WP_000079941.1 NZ_CP122827:70999-71268 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References