Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 55438..56030 Replicon plasmid unnamed4
Accession NZ_CP122827
Organism Escherichia coli strain ETEC1732

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I9ZJC5
Locus tag QDX01_RS26900 Protein ID WP_000513532.1
Coordinates 55438..55686 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1I9ZJ49
Locus tag QDX01_RS26905 Protein ID WP_000681609.1
Coordinates 55683..56030 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX01_RS26860 (50737) 50737..51192 - 456 Protein_65 division plane positioning ATPase MipZ -
QDX01_RS26865 (51790) 51790..52119 + 330 WP_000855121.1 hypothetical protein -
QDX01_RS26870 (52698) 52698..53021 + 324 WP_000427402.1 hypothetical protein -
QDX01_RS26875 (53062) 53062..53271 + 210 WP_000866037.1 hypothetical protein -
QDX01_RS26880 (53369) 53369..53593 + 225 WP_000814383.1 hypothetical protein -
QDX01_RS26885 (53645) 53645..53905 + 261 WP_000702245.1 hypothetical protein -
QDX01_RS26890 (53895) 53895..54146 + 252 WP_000931278.1 transcriptional regulator -
QDX01_RS26895 (54695) 54695..54973 + 279 WP_000545937.1 hypothetical protein -
QDX01_RS26900 (55438) 55438..55686 + 249 WP_000513532.1 type II toxin-antitoxin system HicA family toxin Toxin
QDX01_RS26905 (55683) 55683..56030 + 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDX01_RS26910 (56241) 56241..57449 - 1209 WP_000198533.1 IS91 family transposase -
QDX01_RS26915 (57430) 57430..57702 - 273 WP_000019163.1 hypothetical protein -
QDX01_RS26920 (57970) 57970..59157 - 1188 WP_000937591.1 IS91 family transposase -
QDX01_RS26925 (59157) 59157..59522 - 366 WP_000091308.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aadA5 / sul2 - 1..80827 80827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9378.03 Da        Isoelectric Point: 10.4800

>T277982 WP_000513532.1 NZ_CP122827:55438-55686 [Escherichia coli]
MGKADKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL

Download         Length: 249 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13206.97 Da        Isoelectric Point: 4.8313

>AT277982 WP_000681609.1 NZ_CP122827:55683-56030 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEAETLADLEREFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSHHRAGA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9ZJC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1I9ZJ49

References