Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4802910..4803407 Replicon chromosome
Accession NZ_CP122823
Organism Escherichia coli strain ETEC1732

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDX01_RS24275 Protein ID WP_001173343.1
Coordinates 4802910..4803083 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDX01_RS24280 Protein ID WP_000398619.1
Coordinates 4803111..4803407 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX01_RS24265 (4799580) 4799580..4801037 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QDX01_RS24270 (4801274) 4801274..4802791 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDX01_RS24275 (4802910) 4802910..4803083 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDX01_RS24280 (4803111) 4803111..4803407 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDX01_RS24285 (4803633) 4803633..4803905 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QDX01_RS24290 (4803917) 4803917..4804147 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QDX01_RS24295 (4804328) 4804328..4805959 + 1632 WP_282835009.1 sensor histidine kinase -
QDX01_RS24300 (4805956) 4805956..4806675 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277976 WP_001173343.1 NZ_CP122823:c4803083-4802910 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277976 WP_000398619.1 NZ_CP122823:c4803407-4803111 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References