Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2999384..2999855 Replicon chromosome
Accession NZ_CP122823
Organism Escherichia coli strain ETEC1732

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QDX01_RS15145 Protein ID WP_001303511.1
Coordinates 2999577..2999855 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QDX01_RS15140 Protein ID WP_001302048.1
Coordinates 2999384..2999575 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX01_RS15090 (2994582) 2994582..2994794 - 213 WP_032083143.1 hypothetical protein -
QDX01_RS15095 (2994845) 2994845..2995201 - 357 WP_167851674.1 hypothetical protein -
QDX01_RS15100 (2995203) 2995203..2995874 - 672 WP_135565444.1 ead/Ea22-like family protein -
QDX01_RS15105 (2995871) 2995871..2996467 - 597 WP_135565443.1 ead/Ea22-like family protein -
QDX01_RS15110 (2996454) 2996454..2996759 - 306 WP_033873270.1 DUF4406 domain-containing protein -
QDX01_RS15115 (2996756) 2996756..2997157 - 402 WP_064578958.1 DUF977 family protein -
QDX01_RS15120 (2997200) 2997200..2998147 - 948 WP_112794506.1 helix-turn-helix domain-containing protein -
QDX01_RS15125 (2998171) 2998171..2998596 - 426 WP_000693861.1 toxin YdaT family protein -
QDX01_RS15130 (2998593) 2998593..2998895 - 303 WP_000172735.1 transcriptional regulator -
QDX01_RS15135 (2999007) 2999007..2999363 + 357 WP_282835446.1 hypothetical protein -
QDX01_RS15140 (2999384) 2999384..2999575 + 192 WP_001302048.1 hypothetical protein Antitoxin
QDX01_RS15145 (2999577) 2999577..2999855 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX01_RS15150 (3000147) 3000147..3000302 + 156 WP_000379575.1 DUF1391 family protein -
QDX01_RS15155 (3000304) 3000304..3000432 + 129 WP_000344928.1 protein YdfB -
QDX01_RS15160 (3000462) 3000462..3000668 + 207 WP_001171935.1 hypothetical protein -
QDX01_RS15165 (3000693) 3000693..3001331 + 639 WP_282834735.1 hypothetical protein -
QDX01_RS15170 (3001332) 3001332..3001541 - 210 WP_033813301.1 hypothetical protein -
QDX01_RS15175 (3002106) 3002106..3002294 + 189 WP_089565158.1 cell division inhibition protein DicB -
QDX01_RS15180 (3002291) 3002291..3002494 + 204 WP_097314166.1 DUF1482 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2961668..3010600 48932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T277971 WP_001303511.1 NZ_CP122823:2999577-2999855 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT277971 WP_001302048.1 NZ_CP122823:2999384-2999575 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References