Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 43147..43706 Replicon plasmid unnamed3
Accession NZ_CP122819
Organism Escherichia coli strain ETEC1731

Toxin (Protein)


Gene name relE Uniprot ID A0A733EV64
Locus tag QDY29_RS25670 Protein ID WP_001582571.1
Coordinates 43147..43422 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag QDY29_RS25675 Protein ID WP_001178089.1
Coordinates 43422..43706 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY29_RS25645 (39450) 39450..40796 - 1347 WP_001132032.1 protein YagA -
QDY29_RS25650 (41150) 41150..41752 + 603 WP_000517695.1 ProQ/FINO family protein -
QDY29_RS25655 (41808) 41808..42302 + 495 WP_001582574.1 hypothetical protein -
QDY29_RS25660 (42302) 42302..42568 + 267 WP_000627829.1 hypothetical protein -
QDY29_RS25665 (42838) 42838..43041 - 204 Protein_54 hypothetical protein -
QDY29_RS25670 (43147) 43147..43422 - 276 WP_001582571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDY29_RS25675 (43422) 43422..43706 - 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
QDY29_RS25680 (44614) 44614..45645 - 1032 WP_000907861.1 plasmid replication initiator RepA -
QDY29_RS25685 (46603) 46603..46761 + 159 Protein_58 ash family protein -
QDY29_RS25690 (46799) 46799..47086 + 288 WP_000074855.1 conjugal transfer protein TraA -
QDY29_RS25695 (47528) 47528..48061 + 534 WP_001372168.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..91117 91117


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.5296

>T277956 WP_001582571.1 NZ_CP122819:c43422-43147 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT277956 WP_001178089.1 NZ_CP122819:c43706-43422 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A733EV64

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References