Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4479877..4480374 Replicon chromosome
Accession NZ_CP122816
Organism Escherichia coli strain ETEC1731

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDY29_RS21970 Protein ID WP_001173343.1
Coordinates 4479877..4480050 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag QDY29_RS21975 Protein ID WP_001425728.1
Coordinates 4480078..4480374 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY29_RS21960 (4476547) 4476547..4478004 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
QDY29_RS21965 (4478241) 4478241..4479758 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDY29_RS21970 (4479877) 4479877..4480050 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDY29_RS21975 (4480078) 4480078..4480374 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDY29_RS21980 (4480601) 4480601..4480873 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDY29_RS21985 (4480885) 4480885..4481115 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
QDY29_RS21990 (4481296) 4481296..4482927 + 1632 WP_001216487.1 sensor histidine kinase -
QDY29_RS21995 (4482924) 4482924..4483643 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277946 WP_001173343.1 NZ_CP122816:c4480050-4479877 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT277946 WP_001425728.1 NZ_CP122816:c4480374-4480078 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References