Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2470594..2471120 Replicon chromosome
Accession NZ_CP122816
Organism Escherichia coli strain ETEC1731

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag QDY29_RS12190 Protein ID WP_000323025.1
Coordinates 2470833..2471120 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag QDY29_RS12185 Protein ID WP_000534858.1
Coordinates 2470594..2470833 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY29_RS12145 (2465780) 2465780..2466007 + 228 WP_000476993.1 Cro/CI family transcriptional regulator -
QDY29_RS12150 (2465991) 2465991..2466512 + 522 WP_000705349.1 toxin YdaT family protein -
QDY29_RS12155 (2466493) 2466493..2467458 + 966 WP_000054506.1 hypothetical protein -
QDY29_RS12160 (2467499) 2467499..2467918 + 420 WP_001151195.1 DUF977 family protein -
QDY29_RS12165 (2467973) 2467973..2469022 + 1050 Protein_2380 IS1202-like element ISEsa1 family transposase -
QDY29_RS12170 (2469143) 2469143..2469292 + 150 WP_180302674.1 protein YdfW -
QDY29_RS12175 (2469729) 2469729..2470061 - 333 WP_001317460.1 FlxA-like family protein -
QDY29_RS12180 (2470264) 2470264..2470569 - 306 WP_001326990.1 protein YdfV -
QDY29_RS12185 (2470594) 2470594..2470833 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
QDY29_RS12190 (2470833) 2470833..2471120 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
QDY29_RS12195 (2471192) 2471192..2471347 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
QDY29_RS12200 (2471564) 2471564..2471815 + 252 WP_000980994.1 protein Rem -
QDY29_RS12205 (2471882) 2471882..2472160 + 279 WP_012304870.1 hypothetical protein -
QDY29_RS12210 (2472162) 2472162..2473211 + 1050 WP_001265198.1 DUF968 domain-containing protein -
QDY29_RS12215 (2473225) 2473225..2473977 + 753 WP_001047135.1 antitermination protein -
QDY29_RS12220 (2474255) 2474255..2474344 - 90 WP_120795389.1 hypothetical protein -
QDY29_RS12225 (2474399) 2474399..2474611 - 213 WP_000087756.1 cold shock-like protein CspF -
QDY29_RS12230 (2474912) 2474912..2475127 + 216 WP_000066484.1 cold shock-like protein CspB -
QDY29_RS12235 (2475491) 2475491..2475661 - 171 WP_001405948.1 putative zinc-binding protein YnfU -
QDY29_RS12240 (2475881) 2475881..2476096 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2461174..2509990 48816
- inside Prophage - - 2461174..2520299 59125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T277941 WP_000323025.1 NZ_CP122816:2470833-2471120 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp


Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT277941 WP_000534858.1 NZ_CP122816:2470594-2470833 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References