Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4286710..4287341 Replicon chromosome
Accession NC_017906
Organism Escherichia coli Xuzhou21

Toxin (Protein)


Gene name hicA Uniprot ID Q8X5S6
Locus tag CDCO157_RS22215 Protein ID WP_001259386.1
Coordinates 4287066..4287341 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag CDCO157_RS22210 Protein ID WP_000593555.1
Coordinates 4286710..4287069 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDCO157_RS22180 4281822..4282295 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
CDCO157_RS22185 4282292..4282573 + 282 WP_000084025.1 PTS sugar transporter subunit IIB -
CDCO157_RS22190 4282650..4284008 + 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
CDCO157_RS22195 4284001..4285509 + 1509 WP_001301773.1 carbohydrate kinase -
CDCO157_RS22200 4285499..4285768 + 270 WP_000933060.1 HPr family phosphocarrier protein -
CDCO157_RS22205 4285800..4286660 + 861 WP_001131788.1 class II aldolase -
CDCO157_RS22210 4286710..4287069 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CDCO157_RS22215 4287066..4287341 - 276 WP_001259386.1 type II toxin-antitoxin system HicA family toxin Toxin
CDCO157_RS22220 4287414..4288538 - 1125 WP_001301659.1 ABC transporter permease -
CDCO157_RS22225 4288538..4291273 - 2736 WP_000149107.1 ribosome-associated ATPase/putative transporter RbbA -
CDCO157_RS22230 4291270..4292337 - 1068 WP_000361458.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10165.92 Da        Isoelectric Point: 10.7076

>T27794 WP_001259386.1 NC_017906:c4287341-4287066 [Escherichia coli Xuzhou21]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKLILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T27794 NC_017906:c4287341-4287066 [Escherichia coli Xuzhou21]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT27794 WP_000593555.1 NC_017906:c4287069-4286710 [Escherichia coli Xuzhou21]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT27794 NC_017906:c4287069-4286710 [Escherichia coli Xuzhou21]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9WXY7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References