Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1407942..1408567 Replicon chromosome
Accession NZ_CP122816
Organism Escherichia coli strain ETEC1731

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDY29_RS06985 Protein ID WP_000911330.1
Coordinates 1408169..1408567 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QDY29_RS06980 Protein ID WP_000450524.1
Coordinates 1407942..1408169 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY29_RS06955 (1403746) 1403746..1404216 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QDY29_RS06960 (1404216) 1404216..1404788 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QDY29_RS06965 (1404934) 1404934..1405812 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QDY29_RS06970 (1405829) 1405829..1406863 + 1035 WP_001384714.1 outer membrane protein assembly factor BamC -
QDY29_RS06975 (1407076) 1407076..1407789 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QDY29_RS06980 (1407942) 1407942..1408169 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDY29_RS06985 (1408169) 1408169..1408567 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QDY29_RS06990 (1408714) 1408714..1409577 + 864 WP_001267507.1 neutral zinc metallopeptidase -
QDY29_RS06995 (1409592) 1409592..1411607 + 2016 WP_000829335.1 tRNA cytosine(34) acetyltransferase TmcA -
QDY29_RS07000 (1411681) 1411681..1412379 + 699 WP_000679812.1 esterase -
QDY29_RS07005 (1412489) 1412489..1412689 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T277934 WP_000911330.1 NZ_CP122816:1408169-1408567 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT277934 WP_000450524.1 NZ_CP122816:1407942-1408169 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References