Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 938368..939022 Replicon chromosome
Accession NZ_CP122816
Organism Escherichia coli strain ETEC1731

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QDY29_RS04670 Protein ID WP_000244777.1
Coordinates 938615..939022 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDY29_RS04665 Protein ID WP_000354046.1
Coordinates 938368..938634 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY29_RS04640 (933656) 933656..934399 + 744 WP_000951948.1 SDR family oxidoreductase -
QDY29_RS04645 (934456) 934456..935889 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
QDY29_RS04650 (935934) 935934..936245 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
QDY29_RS04655 (936409) 936409..937068 + 660 WP_000250274.1 hemolysin III family protein -
QDY29_RS04660 (937145) 937145..938125 - 981 WP_280080777.1 tRNA-modifying protein YgfZ -
QDY29_RS04665 (938368) 938368..938634 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDY29_RS04670 (938615) 938615..939022 + 408 WP_000244777.1 protein YgfX Toxin
QDY29_RS04675 (939062) 939062..939583 - 522 WP_001055874.1 flavodoxin FldB -
QDY29_RS04680 (939695) 939695..940591 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDY29_RS04685 (940616) 940616..941326 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDY29_RS04690 (941332) 941332..943065 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T277931 WP_000244777.1 NZ_CP122816:938615-939022 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277931 WP_000354046.1 NZ_CP122816:938368-938634 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References