Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 302928..303728 Replicon chromosome
Accession NZ_CP122816
Organism Escherichia coli strain ETEC1731

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag QDY29_RS01440 Protein ID WP_000342449.1
Coordinates 303201..303728 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag QDY29_RS01435 Protein ID WP_001277108.1
Coordinates 302928..303194 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY29_RS01415 (298585) 298585..299253 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QDY29_RS01420 (299246) 299246..300304 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
QDY29_RS01425 (300549) 300549..301403 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QDY29_RS01430 (301675) 301675..302778 + 1104 WP_001350438.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QDY29_RS01435 (302928) 302928..303194 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QDY29_RS01440 (303201) 303201..303728 + 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QDY29_RS01445 (303725) 303725..304108 - 384 WP_000778781.1 aspartate 1-decarboxylase autocleavage activator PanM -
QDY29_RS01450 (304532) 304532..305641 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QDY29_RS01455 (305689) 305689..306615 + 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QDY29_RS01460 (306612) 306612..307889 + 1278 WP_000803799.1 branched chain amino acid ABC transporter permease LivM -
QDY29_RS01465 (307886) 307886..308653 + 768 WP_000082091.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T277927 WP_000342449.1 NZ_CP122816:303201-303728 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT277927 WP_001277108.1 NZ_CP122816:302928-303194 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References