Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 281637..282223 Replicon chromosome
Accession NZ_CP122816
Organism Escherichia coli strain ETEC1731

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag QDY29_RS01315 Protein ID WP_042014162.1
Coordinates 281637..281867 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QDY29_RS01320 Protein ID WP_000593555.1
Coordinates 281864..282223 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY29_RS01305 (277674) 277674..280409 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
QDY29_RS01310 (280409) 280409..281533 + 1125 WP_001314210.1 ABC transporter permease -
QDY29_RS01315 (281637) 281637..281867 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
QDY29_RS01320 (281864) 281864..282223 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDY29_RS01325 (282343) 282343..282744 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QDY29_RS01330 (282750) 282750..283556 - 807 WP_282842835.1 nickel import ATP-binding protein NikE -
QDY29_RS01335 (283553) 283553..284317 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QDY29_RS01340 (284317) 284317..285150 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QDY29_RS01345 (285147) 285147..286091 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T277926 WP_042014162.1 NZ_CP122816:281637-281867 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT277926 WP_000593555.1 NZ_CP122816:281864-282223 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References