277924

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 1056..1657 Replicon plasmid unnamed8
Accession NZ_CP122809
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name doc Uniprot ID A0A731GHK2
Locus tag QDX84_RS28100 Protein ID WP_001216038.1
Coordinates 1277..1657 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QDX84_RS28095 Protein ID WP_001190712.1
Coordinates 1056..1277 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS28085 (QDX84_28085) 1..390 + 390 WP_022630896.1 S24 family peptidase -
QDX84_RS28090 (QDX84_28090) 525..947 + 423 WP_000098854.1 hypothetical protein -
QDX84_RS28095 (QDX84_28095) 1056..1277 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QDX84_RS28100 (QDX84_28100) 1277..1657 + 381 WP_001216038.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QDX84_RS28105 (QDX84_28105) 1662..1859 + 198 WP_000113017.1 hypothetical protein -
QDX84_RS28110 (QDX84_28110) 1892..2668 - 777 WP_282835463.1 hypothetical protein -
QDX84_RS28115 (QDX84_28115) 2675..3352 - 678 WP_001061873.1 DUF2829 domain-containing protein -
QDX84_RS28120 (QDX84_28120) 3367..3861 - 495 WP_074525592.1 dUTP diphosphatase -
QDX84_RS28125 (QDX84_28125) 3858..4322 - 465 WP_282835462.1 hypothetical protein -
QDX84_RS28130 (QDX84_28130) 4319..4663 - 345 WP_001191776.1 hypothetical protein -
QDX84_RS28135 (QDX84_28135) 4737..5765 - 1029 WP_001292231.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90361 90361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13574.27 Da        Isoelectric Point: 5.1514

>T277924 WP_001216038.1 NZ_CP122809:1277-1657 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEISDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT277924 WP_001190712.1 NZ_CP122809:1056-1277 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A731GHK2

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References