Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 69286..69833 Replicon plasmid unnamed3
Accession NZ_CP122804
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDX84_RS26950 Protein ID WP_244442846.1
Coordinates 69555..69833 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QDX84_RS26945 Protein ID WP_000079941.1
Coordinates 69286..69555 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS26915 (64366) 64366..65070 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
QDX84_RS26920 (65122) 65122..65715 + 594 Protein_83 IS110-like element IS5075 family transposase -
QDX84_RS26925 (65987) 65987..66073 - 87 Protein_84 Arm DNA-binding domain-containing protein -
QDX84_RS26930 (66403) 66403..67218 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
QDX84_RS26935 (67305) 67305..67547 + 243 Protein_86 phosphoglucosamine mutase -
QDX84_RS26940 (67783) 67783..68928 - 1146 Protein_87 IS91-like element ISVsa3 family transposase -
QDX84_RS26945 (69286) 69286..69555 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDX84_RS26950 (69555) 69555..69833 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
QDX84_RS26955 (69873) 69873..70721 + 849 WP_021265674.1 3'-5' exonuclease -
QDX84_RS26960 (70862) 70862..71311 + 450 WP_001236003.1 hypothetical protein -
QDX84_RS26965 (71788) 71788..72054 - 267 WP_000955263.1 hypothetical protein -
QDX84_RS26970 (72054) 72054..72548 - 495 WP_001459505.1 hypothetical protein -
QDX84_RS26975 (72604) 72604..73206 - 603 WP_000517695.1 ProQ/FINO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aadA5 / sul2 - 1..79114 79114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T277916 WP_244442846.1 NZ_CP122804:69555-69833 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT277916 WP_000079941.1 NZ_CP122804:69286-69555 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References