Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 53725..54317 Replicon plasmid unnamed3
Accession NZ_CP122804
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name hicA Uniprot ID A0A1I9ZJC5
Locus tag QDX84_RS26855 Protein ID WP_000513532.1
Coordinates 53725..53973 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1I9ZJ49
Locus tag QDX84_RS26860 Protein ID WP_000681609.1
Coordinates 53970..54317 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS26815 (49024) 49024..49479 - 456 Protein_62 division plane positioning ATPase MipZ -
QDX84_RS26820 (50077) 50077..50406 + 330 WP_000855121.1 hypothetical protein -
QDX84_RS26825 (50985) 50985..51308 + 324 WP_000427402.1 hypothetical protein -
QDX84_RS26830 (51349) 51349..51558 + 210 WP_000866037.1 hypothetical protein -
QDX84_RS26835 (51656) 51656..51880 + 225 WP_000814383.1 hypothetical protein -
QDX84_RS26840 (51932) 51932..52192 + 261 WP_000702245.1 hypothetical protein -
QDX84_RS26845 (52182) 52182..52433 + 252 WP_000931278.1 transcriptional regulator -
QDX84_RS26850 (52982) 52982..53260 + 279 WP_000545937.1 hypothetical protein -
QDX84_RS26855 (53725) 53725..53973 + 249 WP_000513532.1 type II toxin-antitoxin system HicA family toxin Toxin
QDX84_RS26860 (53970) 53970..54317 + 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDX84_RS26865 (54528) 54528..55736 - 1209 WP_000198533.1 IS91 family transposase -
QDX84_RS26870 (55717) 55717..55989 - 273 WP_000019163.1 hypothetical protein -
QDX84_RS26875 (56257) 56257..57444 - 1188 WP_000937591.1 IS91 family transposase -
QDX84_RS26880 (57444) 57444..57809 - 366 WP_000091308.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aadA5 / sul2 - 1..79114 79114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9378.03 Da        Isoelectric Point: 10.4800

>T277915 WP_000513532.1 NZ_CP122804:53725-53973 [Escherichia coli]
MGKADKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
VL

Download         Length: 249 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13206.97 Da        Isoelectric Point: 4.8313

>AT277915 WP_000681609.1 NZ_CP122804:53970-54317 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNILYGKLAFIRDLVTYEAETLADLEREFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSHHRAGA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9ZJC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1I9ZJ49

References