Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4802881..4803390 Replicon chromosome
Accession NZ_CP122801
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name ghoT Uniprot ID -
Locus tag QDX84_RS24285 Protein ID WP_089514152.1
Coordinates 4802881..4803066 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDX84_RS24290 Protein ID WP_000398619.1
Coordinates 4803094..4803390 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS24275 (4799564) 4799564..4801021 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QDX84_RS24280 (4801258) 4801258..4802775 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDX84_RS24285 (4802881) 4802881..4803066 - 186 WP_089514152.1 type V toxin-antitoxin system toxin GhoT Toxin
QDX84_RS24290 (4803094) 4803094..4803390 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDX84_RS24295 (4803616) 4803616..4803888 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QDX84_RS24300 (4803900) 4803900..4804130 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QDX84_RS24305 (4804311) 4804311..4805942 + 1632 WP_282835009.1 sensor histidine kinase -
QDX84_RS24310 (4805939) 4805939..4806658 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-54)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6988.54 Da        Isoelectric Point: 10.2380

>T277909 WP_089514152.1 NZ_CP122801:c4803066-4802881 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFLSFRSCS

Download         Length: 186 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277909 WP_000398619.1 NZ_CP122801:c4803390-4803094 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References