Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
| Location | 4559031..4559845 | Replicon | chromosome |
| Accession | NZ_CP122801 | ||
| Organism | Escherichia coli strain ETEC1734 | ||
Toxin (Protein)
| Gene name | yjhX | Uniprot ID | S1PA82 |
| Locus tag | QDX84_RS22960 | Protein ID | WP_001054376.1 |
| Coordinates | 4559031..4559288 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yjhQ | Uniprot ID | B7MMJ3 |
| Locus tag | QDX84_RS22965 | Protein ID | WP_001338189.1 |
| Coordinates | 4559300..4559845 (+) | Length | 182 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QDX84_RS22935 (4554319) | 4554319..4555425 | + | 1107 | WP_001299704.1 | N-acetylneuraminate epimerase | - |
| QDX84_RS22940 (4555490) | 4555490..4556470 | + | 981 | WP_000991455.1 | sialate O-acetylesterase | - |
| QDX84_RS22945 (4556580) | 4556580..4556785 | + | 206 | Protein_4491 | HNH endonuclease | - |
| QDX84_RS22950 (4557053) | 4557053..4558293 | - | 1241 | Protein_4492 | helicase YjhR | - |
| QDX84_RS22955 (4558409) | 4558409..4558540 | + | 132 | WP_001309182.1 | hypothetical protein | - |
| QDX84_RS22960 (4559031) | 4559031..4559288 | + | 258 | WP_001054376.1 | YjhX family toxin | Toxin |
| QDX84_RS22965 (4559300) | 4559300..4559845 | + | 546 | WP_001338189.1 | N-acetyltransferase | Antitoxin |
| QDX84_RS22970 (4559901) | 4559901..4560647 | + | 747 | WP_000354251.1 | class I SAM-dependent methyltransferase | - |
| QDX84_RS22975 (4560816) | 4560816..4561034 | + | 219 | Protein_4497 | hypothetical protein | - |
| QDX84_RS22980 (4561072) | 4561072..4561188 | + | 117 | Protein_4498 | VOC family protein | - |
| QDX84_RS22985 (4561433) | 4561433..4562554 | + | 1122 | WP_000010829.1 | M42 family metallopeptidase | - |
| QDX84_RS22990 (4562551) | 4562551..4562829 | + | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB SgcB | - |
| QDX84_RS22995 (4562841) | 4562841..4564154 | + | 1314 | WP_000460843.1 | PTS sugar transporter subunit IIC SgcC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimC / fimI / fimA / fimE / fimB | 4548053..4568069 | 20016 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9734.29 Da Isoelectric Point: 11.0090
>T277908 WP_001054376.1 NZ_CP122801:4559031-4559288 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
Download Length: 258 bp
Antitoxin
Download Length: 182 a.a. Molecular weight: 19986.92 Da Isoelectric Point: 6.3277
>AT277908 WP_001338189.1 NZ_CP122801:4559300-4559845 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVTSLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
Download Length: 546 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1PA82 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2KXJ3 |