Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3948120..3948738 Replicon chromosome
Accession NZ_CP122801
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDX84_RS20005 Protein ID WP_001291435.1
Coordinates 3948520..3948738 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDX84_RS20000 Protein ID WP_000344800.1
Coordinates 3948120..3948494 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS19990 (3943209) 3943209..3944402 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDX84_RS19995 (3944425) 3944425..3947574 + 3150 WP_085007940.1 efflux RND transporter permease AcrB -
QDX84_RS20000 (3948120) 3948120..3948494 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDX84_RS20005 (3948520) 3948520..3948738 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDX84_RS20010 (3948910) 3948910..3949461 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDX84_RS20015 (3949577) 3949577..3950047 + 471 WP_000136192.1 YlaC family protein -
QDX84_RS20020 (3950211) 3950211..3951761 + 1551 WP_282834882.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDX84_RS20025 (3951803) 3951803..3952156 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDX84_RS20035 (3952535) 3952535..3952846 + 312 WP_000409911.1 MGMT family protein -
QDX84_RS20040 (3952877) 3952877..3953449 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277905 WP_001291435.1 NZ_CP122801:3948520-3948738 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277905 WP_000344800.1 NZ_CP122801:3948120-3948494 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References