Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2730976..2731614 Replicon chromosome
Accession NZ_CP122801
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDX84_RS13620 Protein ID WP_000813794.1
Coordinates 2731438..2731614 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDX84_RS13615 Protein ID WP_001270286.1
Coordinates 2730976..2731392 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS13595 (2726128) 2726128..2727069 - 942 WP_001251304.1 ABC transporter permease -
QDX84_RS13600 (2727070) 2727070..2728083 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QDX84_RS13605 (2728101) 2728101..2729246 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDX84_RS13610 (2729491) 2729491..2730897 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QDX84_RS13615 (2730976) 2730976..2731392 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDX84_RS13620 (2731438) 2731438..2731614 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDX84_RS13625 (2731836) 2731836..2732066 + 231 WP_000494244.1 YncJ family protein -
QDX84_RS13630 (2732158) 2732158..2734119 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDX84_RS13635 (2734192) 2734192..2734728 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDX84_RS13640 (2734820) 2734820..2735991 + 1172 Protein_2669 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277903 WP_000813794.1 NZ_CP122801:c2731614-2731438 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277903 WP_001270286.1 NZ_CP122801:c2731392-2730976 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References