Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 44889..45436 Replicon plasmid unnamed2
Accession NZ_CP122770
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDY55_RS29190 Protein ID WP_013009346.1
Coordinates 44889..45167 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E0WH52
Locus tag QDY55_RS29195 Protein ID WP_000079932.1
Coordinates 45167..45436 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS29170 (40890) 40890..42236 - 1347 WP_032082920.1 protein YagA -
QDY55_RS29175 (42590) 42590..43183 + 594 WP_000517696.1 ProQ/FINO family protein -
QDY55_RS29180 (43465) 43465..44052 - 588 WP_024189984.1 serine acetyltransferase -
QDY55_RS29185 (44397) 44397..44693 + 297 WP_001419651.1 hypothetical protein -
QDY55_RS29190 (44889) 44889..45167 - 279 WP_013009346.1 type II toxin-antitoxin system toxin YacB Toxin
QDY55_RS29195 (45167) 45167..45436 - 270 WP_000079932.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDY55_RS29200 (45491) 45491..45649 - 159 WP_000841008.1 hypothetical protein -
QDY55_RS29205 (46344) 46344..47375 - 1032 WP_001690254.1 plasmid replication initiator RepA -
QDY55_RS29210 (48333) 48333..48611 + 279 WP_219065241.1 ash family protein -
QDY55_RS29215 (48529) 48529..48816 + 288 WP_000074849.1 conjugal transfer protein TraA -
QDY55_RS29220 (49258) 49258..49791 + 534 WP_024185161.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..93447 93447


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10748.35 Da        Isoelectric Point: 8.4615

>T277884 WP_013009346.1 NZ_CP122770:c45167-44889 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
VLRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10268.58 Da        Isoelectric Point: 7.2055

>AT277884 WP_000079932.1 NZ_CP122770:c45436-45167 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5U8RN22

References