Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 5091343..5091840 Replicon chromosome
Accession NZ_CP122768
Organism Escherichia coli strain ETEC1738

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDY55_RS25510 Protein ID WP_001173343.1
Coordinates 5091343..5091516 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDY55_RS25515 Protein ID WP_000398619.1
Coordinates 5091544..5091840 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY55_RS25500 (5088013) 5088013..5089470 + 1458 WP_000856827.1 dipeptide/tripeptide permease DtpC -
QDY55_RS25505 (5089707) 5089707..5091224 + 1518 WP_000003806.1 lysine--tRNA ligase -
QDY55_RS25510 (5091343) 5091343..5091516 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDY55_RS25515 (5091544) 5091544..5091840 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDY55_RS25520 (5092067) 5092067..5092339 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDY55_RS25525 (5092351) 5092351..5092581 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
QDY55_RS25530 (5092762) 5092762..5094393 + 1632 WP_001216482.1 sensor histidine kinase -
QDY55_RS25535 (5094390) 5094390..5095109 + 720 WP_000611296.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5079278..5091840 12562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277882 WP_001173343.1 NZ_CP122768:c5091516-5091343 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277882 WP_000398619.1 NZ_CP122768:c5091840-5091544 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References